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. 2012 Apr 30:213-214:28-37.
doi: 10.1016/j.jhazmat.2012.01.034. Epub 2012 Jan 20.

Particulate matter (PM10) exposure induces endothelial dysfunction and inflammation in rat brain

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Particulate matter (PM10) exposure induces endothelial dysfunction and inflammation in rat brain

Lin Guo et al. J Hazard Mater. .

Abstract

Epidemiological studies suggest that particulate matter (PM(10)) inhalation was associated with adverse effects on brain-related health, however, existing experimental data lacked relevant evidences. In this study, we treated Wistar rats with PM(10) at different concentrations (0.3, 1, 3 and 10 mg/kg body weight (bw)), and investigated endothelial dysfunction and inflammatory responses in the brain. The results indicate that mild pathological abnormal occurred after 15-day exposure (five times with 3 days each), followed by the changes of endothelial mediators (ET-1 and eNOS) and inflammatory markers (IL-1β, TNF-α, COX-2, iNOS and ICAM-1). Also, the sample up-regulated bax/bcl-2 ratio and p53 expression, and induced neuronal apoptosis. It implicates that PM(10) exerted injuries to mammals' brain, and the mechanisms might be involved in endothelial dysfunction and inflammatory responses.

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