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doi: 10.1016/j.neuron.2012.02.006.
In vivo spreading of tau pathology
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- PMID: 22365536
- DOI: 10.1016/j.neuron.2012.02.006
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In vivo spreading of tau pathology
Neuron.
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Free article
Abstract
Recent findings have suggested that tau pathology may spread in the brain by a prion-like mechanism. In this issue of Neuron, de Calignon et al. (2012) recreated an early stage of neurofibrillary tangle pathology to show that tau aggregates initially generated in a circumscribed area spread throughout the brain and lead to neurodegeneration.
Copyright © 2012 Elsevier Inc. All rights reserved.
Comment on
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Propagation of tau pathology in a model of early Alzheimer's disease.Neuron. 2012 Feb 23;73(4):685-97. doi: 10.1016/j.neuron.2011.11.033. Neuron. 2012. PMID: 22365544 Free PMC article.
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