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Comment
. 2012 Feb 23;73(4):621-3.
doi: 10.1016/j.neuron.2012.02.006.

In vivo spreading of tau pathology

Claudio Soto  1
Affiliations
Free article
Comment

In vivo spreading of tau pathology

Claudio Soto. Neuron. .
Free article

Abstract

Recent findings have suggested that tau pathology may spread in the brain by a prion-like mechanism. In this issue of Neuron, de Calignon et al. (2012) recreated an early stage of neurofibrillary tangle pathology to show that tau aggregates initially generated in a circumscribed area spread throughout the brain and lead to neurodegeneration.

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  • Propagation of tau pathology in a model of early Alzheimer's disease.
    de Calignon A, Polydoro M, Suárez-Calvet M, William C, Adamowicz DH, Kopeikina KJ, Pitstick R, Sahara N, Ashe KH, Carlson GA, Spires-Jones TL, Hyman BT. de Calignon A, et al. Neuron. 2012 Feb 23;73(4):685-97. doi: 10.1016/j.neuron.2011.11.033. Neuron. 2012. PMID: 22365544 Free PMC article.

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