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. 2012 Apr:50:296-303.
doi: 10.1016/j.ejmech.2012.02.008. Epub 2012 Feb 11.

Three novel cyclic hexapeptides from Streptomyces alboflavus 313 and their antibacterial activity

Zhiqin Ji  1 , Shaopeng Wei, Lixia Fan, Wenjun Wu
Affiliations

Three novel cyclic hexapeptides from Streptomyces alboflavus 313 and their antibacterial activity

Zhiqin Ji et al. Eur J Med Chem. 2012 Apr.

Abstract

Three novel cyclic hexapeptides, designated NW-G05 (1), NW-G06 (2) and NW-G07 (3), were isolated from the fermentation broth of Streptomyces alboflavus 313. Their structures were elucidated on the basis of extensive spectroscopic analysis, MS experiments, and chemical analysis. Their antibacterial activities against several strains of bacteria were evaluated by micro-broth dilution method. Among these compounds, NW-G06 (2) and NW-G07 (3) displayed highly antibacterial activity against gram-positive bacteria, but not gram negative ones. However, NW-G05 (1) was not active against all tested microorganisms.

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