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. 2012 Apr 1;22(7):2534-5.
doi: 10.1016/j.bmcl.2012.01.135. Epub 2012 Feb 8.

Oroxylin A analogs exhibited strong inhibitory activities against iNOS-mediated nitric oxide (NO) production

Tuan-Ahn N Pham  1 , Haiyan Che, Phuong-Thuy T Phan, Jae-Won Lee, Sung-Soo Kim, Haeil Park
Affiliations

Oroxylin A analogs exhibited strong inhibitory activities against iNOS-mediated nitric oxide (NO) production

Tuan-Ahn N Pham et al. Bioorg Med Chem Lett. .

Abstract

A number of oroxylin A analogs were prepared and evaluated for their inhibitory activities against iNOS-mediated nitric oxide (NO) production from LPS-stimulated BV2 cells. The analogs were synthesized from purchased 2'-hydroxy-4,5,6-trimethoxyacetophenone and aldehydes in 3 steps. Among the tested compounds, several analogs (3b, 3c, 3d, 3f) exhibited strong inhibitory activities. Especially, the analog with 4-nitrophenyl group (3b) showed stronger inhibitory activity (IC(50)=4.73 μM) than that of wogonin (IC(50)=7.80 μM).

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