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. 2012 Mar-Apr;32(2):127-30.
doi: 10.5144/0256-4947.2012.127.

Association of interleukin-4 polymorphisms with multiple sclerosis in southeastern Iranian patients

Mohammad Kazemi Arababadi  1 , Reza Mosavi, Ali Ravari, Hossein Teimori, Gholamhossein Hassanshahi
Affiliations

Association of interleukin-4 polymorphisms with multiple sclerosis in southeastern Iranian patients

Mohammad Kazemi Arababadi et al. Ann Saudi Med. 2012 Mar-Apr.

Abstract

Background and objectives: Immune system-related factors are important in the pathogenesis of multiple sclerosis (MS). Interleukin 4 (IL-4) as a helper T cell (2TH) cytokine is involved in the regulation of immune responses. Hence, this study was designed to explore the association between MS and polymorphisms in the -590 region of IL-4.

Design and setting: A descriptive study at Rafsanjan University of Medical Sciences, Rafsnajan from September 2009 to August 2010.

Patients and methods: Blood samples were collected from 100 MS patients and 150 healthy controls on EDTA precoated tubes. DNA was extracted and analyzed for IL-4 polymorphisms using restricted fragment length polymorphism in patients and controls. Demographic data were also collected by a questionnaire that was designed specifically for this study.

Results: We observed a significant difference in the C/C, T/C, and T/T genotypes of the -590 region of IL-4 between patients with MS and healthy controls (P<.001).

Conclusions: We conclude that functional polymorphisms of IL-4 possibly play a crucial role in the pathogenesis of MS.

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