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Comment
. 2012 Feb 27;44(3):235-6.
doi: 10.1038/ng.2207.

From HLA association to function

Jeffrey C Barrett  1
Affiliations
Comment

From HLA association to function

Jeffrey C Barrett. Nat Genet. .

Abstract

A new study refines the association signals for rheumatoid arthritis susceptibility in the major histocompatibility complex (MHC) region to five amino-acid positions encoded in three HLA genes, all within peptide-binding grooves. By adapting statistical methods from genome-wide association studies (GWAS) and using imputation from a large reference panel, they demonstrate the potential for this approach to identify functional variants in associated regions.

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References

    1. Nat Genet. 2012 Jan 29;44(3):291-6 - PubMed
    1. Genes Immun. 2004 May;5(3):151-7 - PubMed
    1. Am J Hum Genet. 2008 Jan;82(1):48-56 - PubMed
    1. Nature. 2011 Aug 10;476(7359):214-9 - PubMed
    1. Arthritis Res Ther. 2011 Feb 01;13(1):101 - PubMed

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