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Review
. 2012 Feb 24;17(3):2367-77.
doi: 10.3390/molecules17032367.

Beauvericin, a bioactive compound produced by fungi: a short review

Qinggui Wang  1 , Lijian Xu
Affiliations
Review

Beauvericin, a bioactive compound produced by fungi: a short review

Qinggui Wang et al. Molecules. .

Abstract

Beauvericin is a cyclic hexadepsipeptide mycotoxin, which has insecticidal, antimicrobial, antiviral and cytotoxic activities. It is a potential agent for pesticides and medicines. This paper reviews the bioactivity, fermentation and biosynthesis of the fungal product beauvericin.

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Figures

Figure 1
Figure 1
Beauvericin structure.
Figure 2
Figure 2
Mechanism of beauvericin cytotoxicity to a human leukemia cell (*beauvericin induced extracellular Ca2+ movement into the cell resulting in an increase in the level of intracellular Ca2+; dashed arrows indicate the specific mechanisms that are unclear).
Figure 3
Figure 3
A, Beauvericin biosynthesis pathway; B, The specific substeps of the key step (formula image represents the beauvericin synthetase; the dashed frame indicates the key step of beauvericin synthesis); C, The possible structure of the beauvericin synthetase (E1 is the D-HYIV module; E2 is the L-Phe module; SH1,2,3 are the 4'-phosphopantetheine residues corresponding to D-HYIV, L-Phe, and the linear hexadepsipeptide acceptor; M is the N-methyltransferase domain; Cy is the cyclization cavity).
See this image and copyright information in PMC

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