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. 2012:8:79-86.
doi: 10.2147/TCRM.S23875. Epub 2012 Feb 17.

Daptomycin approved in Japan for the treatment of methicillin-resistant Staphylococcus aureus

Mao Hagihara  1 , Takumi Umemura, Takeshi Mori, Hiroshige Mikamo
Affiliations

Daptomycin approved in Japan for the treatment of methicillin-resistant Staphylococcus aureus

Mao Hagihara et al. Ther Clin Risk Manag. 2012.

Abstract

Daptomycin is a lipoglycopeptide antibacterial drug that is rapidly bactericidal for methicillin-resistant Staphylococcus aureus (MRSA) infection and has antibiotic activity against a wide range of Gram-positive organisms. It has been approved by the Ministry of Health, Labor and Welfare in Japan for the treatment for bacteremia, right-sided endocarditis, and skin and skin-structure infections, such as necrotizing fasciitis, due to MRSA on the basis of a Phase III trial conducted in Japan since July, 2011. In Japanese Phase I and III trials, daptomycin therapy given at 4 mg/kg and 6 mg/kg once per day was well tolerated and effective as standard therapy for the treatment of acute bacterial skin and skin-structure infections and bacteremia caused by MRSA, but side effects remain to be evaluated in large-scale trials.

Keywords: Japan; daptomycin; methicillin-resistant Staphylococcus aureus (MRSA).

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