Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Dec;11(12):960-7.
doi: 10.5812/kowsar.1735143X.805. Epub 2011 Dec 20.

Clinical Features and Seroepidemiology of Anti-HDV Antibody in patients With Chronic Hepatitis B Virus Infection in Iran: A Meta-Analysis

Neda Amini  1 , Seyed Moayed Alavian, Ali Kabir, Seyed Yaser Saiedi Hosseini, Seyed Hossein Aalaei Andabili
Affiliations

Clinical Features and Seroepidemiology of Anti-HDV Antibody in patients With Chronic Hepatitis B Virus Infection in Iran: A Meta-Analysis

Neda Amini et al. Hepat Mon. 2011 Dec.

Abstract

Context: Hepatitis delta virus (HDV) leads to the most severe form of chronic viral hepatitis.

Objectives: To determine the prevalence of HDV and create pooled estimations of possible risk factors, a systematic review was conducted to collect all epidemiological studies on HDV among chronic hepatitis B patients in Iran.

Data sources: In this systematic review, databases such as PubMed, Embase, ISI, Google scholar, and Iranian databases (MagIran, Iranmedex, and SID) were searched.

Study selection: Studies that clearly stated information about the number of HBsAg positive patients infected with HDV were selected.

Data extraction: The name of the city, the author's name, year of study, HDV detection method, sample size, HBsAg positive frequency, mean age, total prevalence of HDV, and risk factors were extracted.

Results: The pooled HDV prevalence was 7.8% (95% CI: 5.89 - 9.71). In the survey-data analysis, HDV prevalence was 6.61%. HDV prevalence was 30.47% (95% CI: 9.76 to 51.19), 14.4% (95% CI: 7.72 to 21.07), and 4.94% (95% CI: 3.73 to 6.15) in cirrhotic, chronic-hepatitis, and inactive-carrier patients, respectively. Pooled ORs were calculated for several factors common to Iranian HBsAg-positive patients, including history of blood transfusion [OR: 1.1 (95% CI: 0.40 to 2.98)], intravenous drug abuse [OR: 1.6 (95% CI: 0.78 to 3.21)], previous hemodialysis [OR: 1.72 (95% CI: 0.79 to 3.76)], and HBeAg-positive status [OR: 1.26 (95% CI: 0.66 to 2.4)].

Conclusions: The prevalence of HDV is less common in Iran than in endemic regions such as Italy and Turkey; however, it is a severe form of hepatitis in HBsAg-positive patients. The most probable route of HDV transmission is hematologic, which suggests the importance of blood screening for HDV, especially in groups with numerous blood transfusions.

Keywords: Epidemiology; Hepatitis D; Iran; Meta-Analysis; Revalence; Review.

PubMed Disclaimer

Figures

Diagram 1
Diagram 1
Article Selection Process for HDV Infection in Iran up to December 2010
Figure 1
Figure 1
Forest plot of HDV Infection prevalence Among HBsAg-positive Patients in Iran, 1983-2008
Figure 2
Figure 2
Regional Distribution of Pooled or Individual Prevalence of Hepatitis D Virus Infection Among HBsAg-positive patients in Iran, 1983-2008
See this image and copyright information in PMC

References

    1. Sagnelli E, Coppola N, Scolastico C, Filippini P, Santantonio T, Stroffolini T, Piccinino F. Virologic and clinical expressions of reciprocal inhibitory effect of hepatitis B, C, and delta viruses in patients with chronic hepatitis. Hepatology. 2000;32(5):1106–10. - PubMed
    1. Fattovich G, Boscaro S, Noventa F, Pornaro E, Stenico D, Alberti A, Ruol A, Realdi G. Influence of hepatitis delta virus infection on progression to cirrhosis in chronic hepatitis type B. J Infect Dis. 1987;155(5):931–5. - PubMed
    1. Romeo R, Del Ninno E, Rumi M, Russo A, Sangiovanni A, de Franchis R, Ronchi G, Colombo M. A 28-year study of the course of hepatitis Delta infection: a risk factor for cirrhosis and hepatocellular carcinoma. Gastroenterology. 2009;136(5):1629–38. - PubMed
    1. Alavian SM, Alavian SH. Hepatitis D virus Infection; Iran, Middle East and Central Asia. Hepat Mon. 2005;5(4):137–43.
    1. Farci P. Delta hepatitis: an update. J Hepatol. 2003;39(Suppl 1):S212–9. - PubMed

LinkOut - more resources