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. 2012 Feb 27:5:4.
doi: 10.1186/1757-1146-5-4.

Cost-effectiveness of cryotherapy versus salicylic acid for the treatment of plantar warts: economic evaluation alongside a randomised controlled trial (EVerT trial)

Eugena Stamuli  1 , Sarah Cockayne, Catherine Hewitt, Kate Hicks, Shalmini Jayakody, Arthur Ricky Kang'ombe, Gwen Turner, Kim Thomas, Mike Curran, Farina Hashmi, Caroline McIntosh, Nichola McLarnon, David J Torgerson, Ian Watt; EVerT team
Affiliations

Cost-effectiveness of cryotherapy versus salicylic acid for the treatment of plantar warts: economic evaluation alongside a randomised controlled trial (EVerT trial)

Eugena Stamuli et al. J Foot Ankle Res. .

Abstract

Background: Plantar warts (verrucae) are extremely common. Although many will spontaneously disappear without treatment, treatment may be sought for a variety of reasons such as discomfort. There are a number of different treatments for cutaneous warts, with salicylic acid and cryotherapy using liquid nitrogen being two of the most common forms of treatment. To date, no full economic evaluation of either salicylic acid or cryotherapy has been conducted based on the use of primary data in a pragmatic setting. This paper describes the cost-effectiveness analysis which was conducted alongside a pragmatic multicentre, randomised trial evaluating the clinical effectiveness of cryotherapy versus 50% salicylic acid of the treatment of plantar warts.

Methods: A cost-effectiveness analysis was undertaken alongside a pragmatic multicentre, randomised controlled trial assessing the clinical effectiveness of 50% salicylic acid and cryotherapy using liquid nitrogen at 12 weeks after randomisation of patients. Cost-effectiveness outcomes were expressed as the additional cost required to completely cure the plantar warts of one additional patient. A NHS perspective was taken for the analysis.

Results: Cryotherapy costs on average £101.17 (bias corrected and accelerated (BCA) 95% CI: 85.09-117.26) more per participant over the 12 week time-frame, while there is no additional benefit, in terms of proportion of patients healed compared with salicylic acid.

Conclusions: Cryotherapy is more costly and no more effective than salicylic acid.

Trial registration: Current Controlled Trials ISRCTN18994246 [controlled-trials.com] and National Research Register N0484189151.

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Figures

Figure 1
Figure 1
Cost-effectiveness plane.
Figure 2
Figure 2
Cost-effectiveness acceptability curve.
See this image and copyright information in PMC

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References

    1. Beliaeva TL. The population incidence of warts. Vestn Dermatol Venerol. 1990;2:55–58. - PubMed
    1. Kilkenny M, Merlin K, Young R, Marks R. The prevalence of common skin conditions in Australian school students: common plane and plantar viral warts. Br J Dermatol. 1998;138:840–845. doi: 10.1046/j.1365-2133.1998.02222.x. - DOI - PubMed
    1. Williams HC, Pottier A, Strachan D. The descriptive epidemiology of warts in British schoolchildren. Br J Dermatol. 1993;128:504–511. doi: 10.1111/j.1365-2133.1993.tb00226.x. - DOI - PubMed
    1. Gibbs S, Harvey I. Topical treatments for cutaneous warts. Cochrane Database Syst Rev. 2006. p. Art.No.:CD001781. DOI:10.1002/14651858.CD001781.pub2. - PubMed
    1. Youn SH, Kwon KI, Park EJ, Kim KH, Kim KJ. A two-week interval is better than a three-week interval for reducing the recurrence rate of hand-foot viral warts after cryotherapy: a retrospective review of 560 hand-foot viral warts patients. Ann Dermatol. 2011;23(1):53–60. doi: 10.5021/ad.2011.23.1.53. - DOI - PMC - PubMed