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Randomized Controlled Trial
. 2012 Oct;42(10):2217-24.
doi: 10.1017/S0033291712000256. Epub 2012 Feb 28.

The effect of counselling, graded exercise and usual care for people with chronic fatigue in primary care: a randomized trial

L Ridsdale  1 , M Hurley, M King, P McCrone, N Donaldson
Affiliations
Free PMC article
Randomized Controlled Trial

The effect of counselling, graded exercise and usual care for people with chronic fatigue in primary care: a randomized trial

L Ridsdale et al. Psychol Med. 2012 Oct.
Free PMC article

Abstract

Background: To evaluate the effectiveness of graded exercise therapy (GET), counselling (COUNS) and usual care plus a cognitive behaviour therapy (CBT) booklet (BUC) for people presenting with chronic fatigue in primary care.

Method: A randomized controlled trial in general practice. The main outcome measure was the change in the Chalder fatigue score between baseline and 6 months. Secondary outcomes included a measure of global outcome, including anxiety and depression, functional impairment and satisfaction.

Results: The reduction in mean Chalder fatigue score at 6 months was 8.1 [95% confidence interval (CI) 6.6-10.4] for BUC, 10.1 (95% CI 7.5-12.6) for GET and 8.6 (95% CI 6.5-10.8) for COUNS. There were no significant differences in change scores between the three groups at the 6- or 12-month assessment. Dissatisfaction with care was high. In relation to the BUC group, the odds of dissatisfaction at the 12-month assessment were less for the GET [odds ratio (OR) 0.11, 95% CI 0.02-0.54, p=0.01] and COUNS groups (OR 0.13, 95% CI 0.03-0.53, p=0.004).

Conclusions: Our evidence suggests that fatigue presented to general practitioners (GPs) tends to remit over 6 months to a greater extent than found previously. Compared to BUC, those treated with graded exercise or counselling therapies were not significantly better with respect to the primary fatigue outcome, although they were less dissatisfied at 1 year. This evidence is generalizable nationally and internationally. We suggest that GPs ask patients to return at 6 months if their fatigue does not remit, when therapy options can be discussed further.

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Figures

Fig. 1
Fig. 1
The flow of participants. BUC, Usual care plus a cognitive behaviour therapy (CBT) booklet; GET, graded exercise therapy.
See this image and copyright information in PMC

References

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