Risk of colorectal cancer in relation to frequency and total amount of red meat consumption. Systematic review and meta-analysis

Abstract

Introduction: The colon and rectum are common sites of food-related cancer in developed countries. Recent studies strongly suggest that red meat intake is associated with colon cancer, whereas for rectal cancer such an association still needs to be proved. The aim of the study was to assess the role of total amount and frequency of red meat intake in colorectal carcinogenesis based on published data using meta-analysis methods.

Material and methods: The literature published until 2009 was selected from: MEDLINE, PubMed, Scopus, Embase, CancerLit, Google Scholar and Cochrane Library databases. The used search terms were: colorectal cancer, colon cancer, rectal cancer, meat intake, red meat intake, red meat consumption, meat consumption, colorectal cancer risk, colon cancer risk, rectal cancer risk and lifestyle. Articles investigating red meat intake of more often than once a day or 50 g per day were reviewed and selected for further analysis.

Results: Twenty-two studies fulfilled the established criteria. A meta-analysis confirmed the carcinogenic effect of the consumption of over 50 g of red meat per day for the colon (relative risk 1.21, 1.07-1.37) but not for the rectum (relative risk 1.30, 0.90-1.89). Red meat intake more frequently than once a day can induce both colonic (relative risk 1.37, 1.09-1.71) and rectal cancer (relative risk 1.43, 1.24-1.64).

Conclusions: Red meat intake is associated with elevated risk of developing colorectal cancer. The frequency of red meat consumption rather than total amount of consumed meat is associated with a higher risk of colorectal carcinogenesis.

Keywords: cancer risk; colorectal cancer; diet; meat consumption.

Figure 1

Study selection process of articles considering red meat intake and risk of colorectal cancer development

Figure 2

Red meat intake over 50 g/day and relative risk of colon cancer development. Summary metaanalysis plot with random effect

Figure 3

Red meat intake over 50 g/day and relative risk of rectal cancer development. Summary metaanalysis plot with random effect

Figure 4

Red meat intake more frequent than once a day and relative risk of colon cancer development. Summary meta-analysis plot with random effect

Figure 5

Red meat intake more frequent than once a day and relative risk of rectal cancer development. Summary meta-analysis plot with random effect