[Renal regulation of the acid-base equilibrium]

Abstract

The kidney controls extracellular bicarbonate concentration and the pH of the body by modulating neat acid excretion (ammonium plus titratable acidity minus bicarbonate) according to the systemic acid-base balance. Proton, bicarbonate and phosphate transport and ammonium synthesis in the proximal tubules change in a homeostatic manner. The intercalycial A (proton secreting) and B cells (bicarbonate secreting) of the distal tubule and cortical collecting ducts have a high capacity of adaptation. The wide ascending branch of the loop of Henle also plays an important role in the bicarbonate and ammonium transport. Recent data suggest a pluri-hormonal regulation of urinary acidification. Therefore, the precision of the renal response to metabolic acidosis depends on the coordinated regulation of different segments of the nephron by the parathyroid hormone, aldosterone and the glucocorticosteroids.