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. 2012 May;6(3):e16-20.
doi: 10.1111/j.1750-2659.2012.00347.x. Epub 2012 Feb 28.

Course of pandemic influenza A(H1N1) 2009 virus infection in Dutch patients

Ingrid H M Friesema  1 , Adam Meijer, Arianne B van Gageldonk-Lafeber, Mariken van der Lubben, Janko van Beek, Gé A Donker, Jan M Prins, Menno D de Jong, Simone Boskamp, Leslie D Isken, Marion P G Koopmans, Marianne A B van der Sande; Dutch ZonMw Influenza A(H1N1) 2009 consortium
Collaborators, Affiliations

Course of pandemic influenza A(H1N1) 2009 virus infection in Dutch patients

Ingrid H M Friesema et al. Influenza Other Respir Viruses. 2012 May.

Abstract

The clinical dynamics of influenza A(H1N1) 2009 infections in 61 laboratory-confirmed Dutch cases were examined. An episode lasted a median of 7·5 days of which 2 days included fever. Respiratory symptoms resolved slowly, while systemic symptoms peaked early in the episode and disappeared quickly. Severity of each symptom was rated highest in the first few days. Furthermore, diarrhoea was negatively associated with viral load, but not with faecal excretion of influenza virus. Cases with comorbidities appeared to have higher viral loads than the cases without, suggesting a less effective immune response. These results complement information obtained through traditional surveillance.

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Figures

Figure 1
Figure 1
Duration of clinical symptoms, showing median, 90‐percentile and 95‐percentile per symptom.
Figure 2
Figure 2
Percentage of cases reporting the experience of each symptom per day.
Figure 3
Figure 3
Median severity score (1–10) per day per symptom as reported by the cases (when reported by at least six cases per day).
See this image and copyright information in PMC

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