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. 2012 Feb 29;14(3):224-30.
doi: 10.1038/ncb2420.

Multiple modes of cytoplasmic dynein regulation

Richard B Vallee  1 , Richard J McKenney, Kassandra M Ori-McKenney
Affiliations

Multiple modes of cytoplasmic dynein regulation

Richard B Vallee et al. Nat Cell Biol. .

Abstract

In performing its multiple cellular functions, the cytoplasmic dynein motor is subject to complex regulation involving allosteric mechanisms within the dynein complex, as well as numerous extramolecular interactions controlling subcellular targeting and motor activity. Recent work has distinguished high- and low-load regulatory modes for cytoplasmic dynein, which, combined with a diversity of targeting mechanisms, accounts for a very broad range of functions.

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References

    1. Cell Host Microbe. 2009 Dec 17;6(6):523-35 - PubMed
    1. EMBO J. 2007 Apr 4;26(7):1853-64 - PubMed
    1. J Cell Biol. 2004 Feb 16;164(4):557-66 - PubMed
    1. Proc Natl Acad Sci U S A. 2004 Feb 10;101(6):1491-5 - PubMed
    1. Cell. 2010 Apr 16;141(2):304-14 - PubMed

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