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. 2012 Jan;6(1):10-20.
doi: 10.5009/gnl.2012.6.1.10. Epub 2012 Jan 12.

Gut Hormones and Appetite Control: A Focus on PYY and GLP-1 as Therapeutic Targets in Obesity

Akila De Silva  1 , Stephen R Bloom
Affiliations

Gut Hormones and Appetite Control: A Focus on PYY and GLP-1 as Therapeutic Targets in Obesity

Akila De Silva et al. Gut Liver. 2012 Jan.

Abstract

The global obesity epidemic has resulted in significant morbidity and mortality. However, the medical treatment of obesity is limited. Gastric bypass is an effective surgical treatment but carries significant perioperative risks. The gut hormones, peptide tyrosine tyrosine (PYY) and glucagon-like peptide 1 (GLP-1), are elevated following gastric bypass and have been shown to reduce food intake. They may provide new therapeutic targets. This review article provides an overview of the central control of food intake and the role of PYY and GLP-1 in appetite control. Key translational animal and human studies are reviewed.

Keywords: Appetite; Glucagon-like peptide 1; Gut hormones; Obesity; Peptide tyrosine tyrosine.

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Conflict of interest statement

Akila De Silva has no competing interests to declare. Stephen R. Bloom declares an association with Thiakis, now a subsidiary of Pfizer.

Figures

Fig. 1
Fig. 1
The major determinants of appetite control.
Fig. 2
Fig. 2
The role of PYY and GLP-1 in appetite control. PYY, peptide tyrosine tyrosine; GLP-1, glucagon-like peptide 1; ARC, arcuate nucleus; NPY, neuropeptide Y; AgRP, agouti-related peptide; POMC, pro-opiomelanocortin; CART, cocaine- and amphetamine-regulated transcript; ME, median eminence; AP, area postrema; NTS, nucleus of the tractus solitaries.
See this image and copyright information in PMC

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