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. 2012 Mar;18(3):469-72.
doi: 10.3201/eid1803.111905.

Novel orthobunyavirus in Cattle, Europe, 2011

Bernd Hoffmann  1 , Matthias Scheuch, Dirk Höper, Ralf Jungblut, Mark Holsteg, Horst Schirrmeier, Michael Eschbaumer, Katja V Goller, Kerstin Wernike, Melina Fischer, Angele Breithaupt, Thomas C Mettenleiter, Martin Beer
Affiliations

Novel orthobunyavirus in Cattle, Europe, 2011

Bernd Hoffmann et al. Emerg Infect Dis. 2012 Mar.

Abstract

In 2011, an unidentified disease in cattle was reported in Germany and the Netherlands. Clinical signs included fever, decreased milk production, and diarrhea. Metagenomic analysis identified a novel orthobunyavirus, which subsequently was isolated from blood of affected animals. Surveillance was initiated to test malformed newborn animals in the affected region.

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Figures

Figure 1
Figure 1
Location of farms with PCR-positive cattle (blue dots) in North Rhine-Westphalia, Germany.
Figure 2
Figure 2
A) Phylogenetic relationship between Schmallenberg virus and orthobunyaviruses of the Simbu, Bunyamwera, and California serogroups. International Nucleotide Sequence Database Collaboration accession numbers of the sequences in the analysis are indicated in the tree. The neighbor-joining tree is based on the nucleocapsid gene of the small segment (702 nt). Numbers at nodes represent the percentage of 1,000 bootstrap replicates (values <50 are not shown). Scale bar indicates the estimated number of nt substitutions per site. B) Detection of Schmallenberg virus genome in the blood of experimentally infected calves. The highest genome copy number was detected on postinoculation day 4.
See this image and copyright information in PMC

References

    1. Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ. Basic local alignment search tool. J Mol Biol. 1990;215:403–10. - PubMed
    1. Yanase T, Maeda K, Kato T, Nyuta S, Kamata H, Yamakawa M, et al. The resurgence of Shamonda virus, an African Simbu group virus of the genus Orthobunyavirus, in Japan. Arch Virol. 2005;150:361–9. 10.1007/s00705-004-0419-3 - DOI - PubMed
    1. Yanase T, Aizawa M, Kato T, Yamakawa M, Shirafuji H, Tsuda T. Genetic characterization of Aino and Peaton virus field isolates reveals a genetic reassortment between these viruses in nature. Virus Res. 2010;153:1–7. 10.1016/j.virusres.2010.06.020 - DOI - PubMed
    1. Ogawa Y, Kato K, Tohya Y, Akashi H. Sequence determination and functional analysis of the Akabane virus (family Bunyaviridae) L RNA segment. Arch Virol. 2007;152:971–9. 10.1007/s00705-006-0912-y - DOI - PubMed
    1. Tamura K, Peterson D, Peterson N, Stecher G, Nei M, Kumar S. MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Mol Biol Evol. 2011;28:2731–9. 10.1093/molbev/msr121 - DOI - PMC - PubMed

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