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Randomized Controlled Trial
. 2012 Oct;43(3):303-12.
doi: 10.1016/j.jsat.2011.12.014. Epub 2012 Feb 27.

A double-blind, placebo-controlled trial of modafinil for cocaine dependence

Charles A Dackis  1 , Kyle M Kampman, Kevin G Lynch, Jennifer G Plebani, Helen M Pettinati, Thorne Sparkman, Charles P O'Brien
Affiliations
Randomized Controlled Trial

A double-blind, placebo-controlled trial of modafinil for cocaine dependence

Charles A Dackis et al. J Subst Abuse Treat. 2012 Oct.

Abstract

This is a randomized, double-blind, placebo-controlled study of modafinil treatment for cocaine dependence. Patients (N = 210) who were actively using cocaine at baseline were randomized to 8 weeks of modafinil (0 mg/day, 200 mg/day, or 400 mg/day) combined with once-weekly cognitive-behavioral therapy. Our primary efficacy measure was cocaine abstinence, based on urine benzoylecgonine (BE) levels, with secondary measures of craving, cocaine withdrawal, retention, and tolerability. We found no significant differences between modafinil and placebo patients on any of these measures. However, there was a significant gender difference in that male patients treated with 400 mg/day tended to be more abstinent than their placebo-treated counterparts (p = .06). Our negative findings might be explained by gender differences and/or inadequate psychosocial treatment intensity in patients with severe cocaine dependence.

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Figures

Figure 1
Figure 1
Patient Flow
Figure 2
Figure 2
Cocaine Abstinence Rates in the Overall Sample
Figure 3
Figure 3
Cocaine Abstinence Rates in the Male Patients
Figure 4
Figure 4
Cocaine Abstinence Rates in the Female Patients
See this image and copyright information in PMC

References

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