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Practice Guideline
. 2012 Apr;91(4):734-8.
doi: 10.1038/clpt.2011.355. Epub 2012 Feb 29.

Clinical pharmacogenetics implementation consortium guidelines for HLA-B genotype and abacavir dosing

M A Martin  1 , T E Klein, B J Dong, M Pirmohamed, D W Haas, D L Kroetz; Clinical Pharmacogenetics Implementation Consortium
Affiliations
Practice Guideline

Clinical pharmacogenetics implementation consortium guidelines for HLA-B genotype and abacavir dosing

M A Martin et al. Clin Pharmacol Ther. 2012 Apr.

Abstract

Human leukocyte antigen B (HLA-B) is responsible for presenting peptides to immune cells and plays a critical role in normal immune recognition of pathogens. A variant allele, HLA-B*57:01, is associated with increased risk of a hypersensitivity reaction to the anti-HIV drug abacavir. In the absence of genetic prescreening, hypersensitivity affects ~6% of patients and can be life-threatening with repeated dosing. We provide recommendations (updated periodically at http://www.pharmkgb.org) for the use of abacavir based on HLA-B genotype.

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Figures

Figure 1
Figure 1
Treatment algorithm for clinical use of abacavir based on HLA-B*57:01 genotype. HLA-B, human leukocyte antigen B; HSR, abacavir hypersensitivity reaction.
See this image and copyright information in PMC

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