Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Mar;10(1):14-9.
doi: 10.1007/s12663-010-0058-z. Epub 2011 Mar 25.

Ophthalmic considerations in cleft lip and palate patients

Sonal Anchlia, Krishna Shama Rao, Krishnamurthy Bonanthaya, B Anupama, I Vittal Nayak

Ophthalmic considerations in cleft lip and palate patients

Sonal Anchlia et al. J Maxillofac Oral Surg. 2011 Mar.

Abstract

Cleft lip and palate (CL and P) represents the second most frequently occurring congenital deformity after clubfoot deformity. CL and P could be associated with many other structural abnormalities of the adjacent vital structures of the face. In this study, an attempt was made to identify the abnormalities of the ocular structures seen in patients with isolated CL and P as well as in those with syndromic CL and P. Of the 322 patients with cleft lip and palate screened, 27 (8.3%) had ocular abnormalities. Totally 47 ocular defects were identified in 27 patients. Abnormalities of the eyelid were the commonest accounting for 22% of the total defects (11/47), which includes symblepharon, ectropion, lid colobomas, euryblepharon and ptosis. Second commonest abnormality was squint 8/47 (17%) followed by orbital defects 8/47 (17%) (Telecanthus and Hypertelorism). Abnormalities of the nasolacrimal apparatus 3/47 (6%), refractive errors 7/47 (15%), dermoids 4/47 (6%), cataract 2/47 (4%) and retinal colobomas 2/47 (4%) constituted the rest. Thus, children with cleft lip and palate should be assessed as soon as possible after birth by a multidisciplinary team involving the Pediatrician, Ophthalmologist and specialists from Maxillofacial, ENT and Plastic surgery. The medical problems in this group of children are global and therefore, should not be looked at in isolation.

Keywords: Cleft lip and palate; Congenital deformities; Ocular abnormalities.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Euryblepharon and ectropion
Fig. 2
Fig. 2
Ptosis
Fig. 3
Fig. 3
Coloboma of the left lower eyelid
Fig. 4
Fig. 4
Treacher Collin Syndrome with operated cleft lip and palate
Fig. 5
Fig. 5
Treacher Collin Syndrome with operated cleft lip and palate
Fig. 6
Fig. 6
Blepharocheinoontic syndrome with cleft lip and palate
Fig. 7
Fig. 7
Blepharocheinoontic syndrome with cleft lip and palate
Fig. 8
Fig. 8
Ocular hypertelorism
See this image and copyright information in PMC

References

    1. Sulik KK. Caniofacial development. In: Turvey TA, Vig KWL, editors. Facial clefts and craniosynostosis and principles and management. Philadelphia: WB Saunders Company; 1996. pp. 3–27.
    1. Nema HV, Singh VP, Nema N. Congenital anomalies of eye and adnexa. In: Agarwal S, Agarwal A, editors. Text book of ophthalmology; retina and vitreous in systemic diseases. 1. New Delhi: Jaypee Brothers; 2002. pp. 2939–2964.
    1. Tassabehji M, Read AP, Newton VE, Harris R, Balling R, Gruss P, Strachan T. Waardenburg’s syndrome patients have mutations in the human homologue of the Pax-3 paired box gene. Nature. 1992;355(6361):635–636. doi: 10.1038/355635a0. - DOI - PubMed
    1. Poswillo D. The aetiology and surgery of cleft palate with micrognathia. Ann R Coll Surg Engl. 1968;43(2):61–88. - PMC - PubMed
    1. Leck I, Hay S, Witte JJ, Greene JC. Malformations recorded on birth certificates following A2 influenza epidemics. Public Health Rep. 1969;84(11):971–979. - PMC - PubMed

LinkOut - more resources