Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Mar;10(1):45-9.
doi: 10.1007/s12663-011-0182-4. Epub 2011 Feb 25.

Platelet concentrates: past, present and future

Shobha Prakash, Aditi Thakur

Platelet concentrates: past, present and future

Shobha Prakash et al. J Maxillofac Oral Surg. 2011 Mar.

Abstract

Platelets play a crucial role in hemostasis and wound healing, platelet growth factors are well known source of healing cytokines. Numerous techniques of autologous platelet concentrates have been developed and applied in oral and maxillofacial surgery. This review describes the evolution of the first and second generation of platelet concentrates (platelet rich plasma and platelet rich fibrin respectively) from their fore runner-fibrin sealants.

Keywords: Fibrin sealants; Platelet growth factors; Platelet rich fibrin; Platelet rich plasma; Wound healing.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Blood processing with a tabletop centrifuge (REMY Laboratories) allows the composition of structured fibrin clot in the middle of the tube, between the red blood cells at the bottom and acellular plasma at the top
Fig. 2
Fig. 2
PRF separated from PPP and RBC layer, ready for placement as a graft alone or in combination with bone graft
See this image and copyright information in PMC

References

    1. Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:e37–e44. doi: 10.1016/j.tripleo.2005.07.008. - DOI - PubMed
    1. Gasling VLW, Acil Y, Springer IN, Hubert N, Wiltfag J. Platelet-rich plasma and platelet-rich fibrin in human cell culture. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;108:45–48. doi: 10.1016/j.tripleo.2009.02.007. - DOI - PubMed
    1. Dohan Ehrenfest DM, Diss A, Odin G, Doglioli P, Hippolyte MP, Charrier JB. In vitro effects of Choukroun’s PRF on human gingival fibroblasts, dermal prekeratinocytes, preadipocytes, and maxillofacial osteoblasts in primary cultures. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;108(3):341–352. doi: 10.1016/j.tripleo.2009.04.020. - DOI - PubMed
    1. Soffer E, Ouhayoun JP, Anagnostou F. Fibrin sealants and platelet preparations in bone and periodontal healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003;95:521–528. doi: 10.1067/moe.2003.152. - DOI - PubMed
    1. Becker W. Fibrin sealants in implant and periodontal treatment: case presentations. Compend Contin Educ Dent. 2008;29(3):182–185. - PubMed

LinkOut - more resources