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. 2012 Mar;23(3):353-9.
doi: 10.1016/j.yebeh.2012.01.013. Epub 2012 Feb 29.

Default mode network abnormalities in idiopathic generalized epilepsy

Megan L McGill  1 , Orrin Devinsky, Clare Kelly, Michael Milham, F Xavier Castellanos, Brian T Quinn, Jonathan DuBois, Jonathan R Young, Chad Carlson, Jacqueline French, Ruben Kuzniecky, Eric Halgren, Thomas Thesen
Affiliations

Default mode network abnormalities in idiopathic generalized epilepsy

Megan L McGill et al. Epilepsy Behav. 2012 Mar.

Abstract

Idiopathic generalized epilepsy (IGE) is associated with widespread cortical network abnormalities on electroencephalography. Resting state functional connectivity (RSFC), based on fMRI, can assess the brain's global functional organization and its disruption in clinical conditions. We compared RSFC associated with the 'default mode network' (DMN) between people with IGE and healthy controls. Strength of functional connectivity within the DMN associated with seeds in the posterior cingulate cortex (PCC) and medial prefrontal cortices (MPFC) was compared between people with IGE and healthy controls and was correlated with seizure duration, age of seizure onset and age at scan. Those with IGE showed markedly reduced functional network connectivity between anterior and posterior cortical seed regions. Seizure duration positively correlates with RSFC between parahippocampal gyri and the PCC but negatively correlates with connectivity between the PCC and frontal lobe. The observed pattern of disruption provides evidence for integration- and segregation-type network abnormalities and supports aberrant network organization among people with IGE.

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Conflict of interest statement

Conflict of interest disclosure:

None of the authors has any conflicts of interest to disclose. We confirm that we have read the Journal’s position on issues involved in ethical publication and affirm that this report is consistent with those guidelines.

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