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Review
. 2012 Mar;17(1):59-64.
doi: 10.1007/s10911-012-9246-4. Epub 2012 Mar 1.

Small non-coding RNAs govern mammary gland tumorigenesis

Zuoren Yu  1 , Richard G Pestell
Affiliations
Review

Small non-coding RNAs govern mammary gland tumorigenesis

Zuoren Yu et al. J Mammary Gland Biol Neoplasia. 2012 Mar.

Abstract

Small non-coding RNAs include siRNA, miRNA, piRNA and snoRNA. The involvement of miRNAs in the regulation of mammary gland tumorigenesis has been widely studied while the role for other small non-coding RNAs remains unclear. Here we summarize the involvement of miRNA in breast cancer onset and progression through regulating the cell cycle and cellular proliferation. The regulation of breast cancer stem cells and tumor regeneration by miRNA is reviewed. In addition, the emerging evidence demonstrating the involvement of piRNA and snoRNA in breast cancer is briefly described.

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Figures

Fig. 1
Fig. 1
miRNA regulation of mammary gland tumorigenesis in control of the cell cycle. Through targeting different genes and different cyclin/CDK complexes, miR-17/20 and let-7 regulate the G1-S transition; miR-21 and miR-27a regulate the G2-M checkpoint
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