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Review
. 2012 Jun;9(2):117-27.
doi: 10.1007/s11897-012-0083-y.

Chemotherapy-induced cardiotoxicity

Amir Y Shaikh  1 , Jeffrey A Shih
Affiliations
Review

Chemotherapy-induced cardiotoxicity

Amir Y Shaikh et al. Curr Heart Fail Rep. 2012 Jun.

Abstract

Anthracycline-based chemotherapeutics have long been recognized as effective agents for treating a wide range of malignancies. However, their use is not without significant adverse cardiotoxic side effects. Strategies for prevention involve limiting free-radical production and subsequent cardiac myocyte damage. Dexrazoxane remains the most widely studied cardioprotective medication. Alternative agents may reduce cardiotoxicity but may still cause significant cardiovascular problems. The role of β-blockers and angiotensin-converting enzyme inhibitors in the treatment of heart failure is well proven. The role of these medications in the prevention and treatment of chemotherapy-induced cardiotoxicity is not well established.

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