The Jak/STAT pathway
- PMID: 22383755
- PMCID: PMC3282412
- DOI: 10.1101/cshperspect.a011205
The Jak/STAT pathway
Abstract
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway mediates cellular responses to cytokines (e.g., IL-6) and growth factors (e.g., EGF).
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References
-
- Arbouzova NI, Zeidler MP 2006. JAK/STAT signalling in Drosophila: Insights into conserved regulatory and cellular functions. Development 133: 2605–2616 - PubMed
-
- Darnell JE Jr, Kerr IM, Stark GR 1994. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264: 1415–1421 - PubMed
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