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Review
. 2012 Mar 1;4(3):a011205.
doi: 10.1101/cshperspect.a011205.

The Jak/STAT pathway

Affiliations
Review

The Jak/STAT pathway

Douglas A Harrison. Cold Spring Harb Perspect Biol. .

Abstract

The Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway mediates cellular responses to cytokines (e.g., IL-6) and growth factors (e.g., EGF).

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Figures

Figure 1.
Figure 1.
The JAK/STAT pathway (simplified view).
Figure 2.
Figure 2.
The JAK/STAT pathway.

References

    1. Arbouzova NI, Zeidler MP 2006. JAK/STAT signalling in Drosophila: Insights into conserved regulatory and cellular functions. Development 133: 2605–2616 - PubMed
    1. Darnell JE Jr, Kerr IM, Stark GR 1994. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264: 1415–1421 - PubMed
    1. Dawson MA, Bannister AJ, Gottgens B, Foster SD, Bartke T, Green AR, Kouzarides T 2009. JAK2 phosphorylates histone H3Y41 and excludes HP1a from chromatin. Nature 461: 819–822 - PMC - PubMed
    1. Ghoreschi K, Laurence A, O’Shea JJ 2009. Janus kinases in immune cell signaling. Immunol Rev 228: 273–287 - PMC - PubMed
    1. Haan C, Behrmann I, Haan S 2010. Perspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinases. J Cell Mol Med 14: 504–527 - PMC - PubMed

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