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Meta-Analysis
. 2012;7(2):e32045.
doi: 10.1371/journal.pone.0032045. Epub 2012 Feb 23.

A replication study of the association between rheumatoid arthritis and deletion of the late cornified envelope genes LCE3B and LCE3C

Judith G M Bergboer  1 , Maša Umićević-Mirkov, Jaap Fransen, Martin den Heijer, Barbara Franke, Piet L C M van Riel, Joost Schalkwijk, Marieke J H Coenen; Nijmegen Biomedical Study principal investigators
Affiliations
Meta-Analysis

A replication study of the association between rheumatoid arthritis and deletion of the late cornified envelope genes LCE3B and LCE3C

Judith G M Bergboer et al. PLoS One. 2012.

Abstract

Objective: Two recent studies, in a Spanish and a Chinese population, point to an association between rheumatoid arthritis (RA) risk and the deletion of the Late Cornified Envelope (LCE) 3B and 3C genes (LCE3C_LCE3B-del), a known risk factor for psoriasis. We aimed to replicate these studies in a large Dutch cohort.

Methods: 1039 RA cases and 759 controls were genotyped for LCE3C_LCE3B-del. Association analysis was performed for the complete cohort and after stratification for the serologic markers anti-cyclic citrullinated peptide and rheumatoid factor. A meta-analysis was performed combining our data with the Spanish and Chinese datasets, resulting in an analysis including 2466 RA cases and 2438 controls.

Results: In the Dutch cohort we did not observe a significant association of LCE3C_LCE3B-del (p = 0.093) with RA risk. A stratified analysis for the serologic positive and negative group did not show an association between the genetic variant and disease risk, either. The meta-analysis, however, confirmed a significant association (p<0.0001, OR = 1.31, 95% confidence interval 1.16-1.47).

Conclusion: Our meta-analysis confirms the association of the LCE3 deletion with RA, suggesting that LCE3C_LCE3B-del is a common risk factor for (auto)immune diseases.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

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References

    1. McKinney C, Merriman ME, Chapman PT, Gow PJ, Harrison AA, et al. Evidence for an influence of chemokine ligand 3-like 1 (CCL3L1) gene copy number on susceptibility to rheumatoid arthritis. Ann Rheum Dis. 2008;67:409–413. - PubMed
    1. McKinney C, Fanciulli M, Merriman ME, Phipps-Green A, Alizadeh BZ, et al. Association of variation in Fcgamma receptor 3B gene copy number with rheumatoid arthritis in Caucasian samples. Ann Rheum Dis. 2010;69:1711–1716. - PMC - PubMed
    1. Yim SH, Chung YJ, Jin EH, Shim SC, Kim JY, et al. The potential role of VPREB1 gene copy number variation in susceptibility to rheumatoid arthritis. Mol Immunol. 2011;48:1338–1343. - PubMed
    1. Craddock N, Hurles ME, Cardin N, Pearson RD, Plagnol V, et al. Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature. 2010;464:713–720. - PMC - PubMed
    1. Uddin M, Sturge M, Rahman P, Woods MO. Autosome-wide Copy Number Variation Association Analysis for Rheumatoid Arthritis Using the WTCCC High-density SNP Genotype Data. J Rheumatol. 2011;38:797–801. - PubMed

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