Comment
doi: 10.1016/j.cell.2012.02.006.
Greasing the path to BAX/BAK activation
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- PMID: 22385953
- DOI: 10.1016/j.cell.2012.02.006
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Greasing the path to BAX/BAK activation
Cell.
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Abstract
BAX/BAK activation leading to mitochondrial outer-membrane permeabilization is a key commitment point in apoptosis. Chipuk et al. now identify two sphingolipids as specific cofactors for BAX/BAK activation that lower the threshold for apoptosis-associated cytochrome c release. Association of mitochondria with other cellular membrane compartments is required for BAK/BAX exposure to these sphingolipids.
Copyright © 2012 Elsevier Inc. All rights reserved.
Comment on
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Sphingolipid metabolism cooperates with BAK and BAX to promote the mitochondrial pathway of apoptosis.Cell. 2012 Mar 2;148(5):988-1000. doi: 10.1016/j.cell.2012.01.038. Cell. 2012. PMID: 22385963 Free PMC article.
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