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Comment
. 2012 Mar 2;148(5):845-6.
doi: 10.1016/j.cell.2012.02.006.

Greasing the path to BAX/BAK activation

Emilie Hollville  1 , Seamus J Martin
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Free article
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Greasing the path to BAX/BAK activation

Emilie Hollville et al. Cell. .
Free article

Abstract

BAX/BAK activation leading to mitochondrial outer-membrane permeabilization is a key commitment point in apoptosis. Chipuk et al. now identify two sphingolipids as specific cofactors for BAX/BAK activation that lower the threshold for apoptosis-associated cytochrome c release. Association of mitochondria with other cellular membrane compartments is required for BAK/BAX exposure to these sphingolipids.

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