Comment
doi: 10.1016/j.cell.2012.02.011.
DNA-damage-induced differentiation in hematopoietic stem cells
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- PMID: 22385954
- DOI: 10.1016/j.cell.2012.02.011
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DNA-damage-induced differentiation in hematopoietic stem cells
Cell.
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Abstract
Aging of hematopoietic stem cells (HSCs) is accompanied by diminished functional potential. Wang et al. now provide evidence for an HSC-specific differentiation checkpoint mediated by the transcription factor BATF, which limits self-renewal of HSCs in response to the accumulation of DNA damage.
Copyright © 2012 Elsevier Inc. All rights reserved.
Comment on
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A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage.Cell. 2012 Mar 2;148(5):1001-14. doi: 10.1016/j.cell.2012.01.040. Cell. 2012. PMID: 22385964
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