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Review
. 2012 Apr;24(2):178-83.
doi: 10.1016/j.coi.2012.02.003. Epub 2012 Mar 1.

The development of LTi cells

Marie Cherrier  1 , Gérard Eberl
Affiliations
Review

The development of LTi cells

Marie Cherrier et al. Curr Opin Immunol. 2012 Apr.

Abstract

Lymphoid tissue inducer (LTi) cells are programmed by the mammalian fetus to induce the development of lymph nodes and Peyer's patches. LTi cells share a pro-inflammatory profile with Th17 cells, as well as their requirement for the transcription factor RORγt. We discuss here the latest data on the fetal and post-natal development of LTi cells, and their relationship with the larger family of innate lymphoid cells (ILCs). We suggest that the re-programming of RORγt in a subset of common lymphoid progenitors allowed mammals to develop lymphoid organs before birth, whereas other vertebrates only develop such organs in response to infection or injury.

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