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. 2012 May;36(5):594-7.
doi: 10.1016/j.leukres.2012.02.009. Epub 2012 Mar 3.

Could age modify the effect of genetic variants in IL6 and TNF-α genes in multiple myeloma?

Alessandro Martino  1 , Gabriele Buda, Valentina Maggini, Francesco Lapi, Antonella Lupia, Domenica Di Bello, Enrico Orciuolo, Sara Galimberti, Roberto Barale, Mario Petrini, Anna Maria Rossi
Affiliations

Could age modify the effect of genetic variants in IL6 and TNF-α genes in multiple myeloma?

Alessandro Martino et al. Leuk Res. 2012 May.

Abstract

Cytokines play a central role in multiple myeloma (MM) pathogenesis thus genetic variations within cytokines coding genes could influence MM susceptibility and therapy outcome. We investigated the impact of 8 SNPs in these genes in 202 MM cases and 235 controls also evaluating their impact on therapy outcome in a subset of 91 patients. Despite the overall negative findings, we found a significant age-modified effect of IL6 and TNF-α SNPs, on MM risk and therapy outcome, respectively. Therefore, this observation suggests that genetic variation in inflammation-related genes could be an important mediator of the complex interplay between ageing and cancer.

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