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. 2012 Jul;10(7):812-4.
doi: 10.1016/j.cgh.2012.02.018. Epub 2012 Mar 2.

Common features of patients with autoimmune atrophic gastritis

Emanuela Miceli  1 , Marco Vincenzo Lenti, Donatella Padula, Ombretta Luinetti, Claudia Vattiato, Claudio Maria Monti, Michele Di Stefano, Gino Roberto Corazza
Affiliations

Common features of patients with autoimmune atrophic gastritis

Emanuela Miceli et al. Clin Gastroenterol Hepatol. 2012 Jul.

Abstract

Background & aims: Autoimmune atrophic gastritis (AIG) is characterized by immune-mediated chronic inflammation of the gastric body and fundus, leading to hypo-achlorhydria and vitamin B12 deficiency. We analyzed the clinical features of AIG and sought to identify factors that might be used in diagnosis.

Methods: We collected and analyzed clinical data from 99 consecutive patients (age, 59 ± 17 y) who were diagnosed with AIG, based on histologic factors and the presence of autoantibodies against gastric parietal cells.

Results: Clinical factors that led to a diagnosis of AIG included hematologic findings related to vitamin B12 deficiency (n = 37), incidental histologic evidence in gastric biopsy specimens (n = 34), immune disorders (n = 18; 9 were celiac disease), neurologic symptoms (n = 6), and a family history of AIG (n = 4).

Conclusions: Based on an analysis of 99 consecutive patients with AIG, this disorder is not solely a condition of the elderly. Other features to look for in making a diagnosis of AIG include vitamin B12 deficiency, histologic factors, and immune disorders.

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