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Editorial
. 2012 Mar;107(3):448-50.
doi: 10.1038/ajg.2011.465.

Editorial: fecal granins in IBS: cause or indicator of intestinal or colonic irritation?

Michael Camilleri
Editorial

Editorial: fecal granins in IBS: cause or indicator of intestinal or colonic irritation?

Michael Camilleri. Am J Gastroenterol. 2012 Mar.

Abstract

Ohman et al. report increased fecal granins in patients with irritable bowel syndrome (IBS). Several interesting questions arise from their observations. Are the granins a cause of the pathophysiology or phenotype in IBS? Is the elevation of granins specific to IBS? What is the cause of increased fecal granin levels? Can fecal granin levels be used to diagnose IBS? Are increased fecal granins an expression of intestinal or colonic irritation? This paper adds to the body of evidence suggesting there are gastrointestinal disturbances in IBS; understanding these disturbances may provide clues to its pathogenesis and optimize management.

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Conflict of interest statement

Potential competing interest: None.

Comment on

References

    1. Öhman L, Stridsberg M, Isaksson S, et al. Altered levels of fecal chromogranins and secretogranins in IBS: relevance for pathophysiology and symptoms? Am J Gastroenterol. 2012;107:440–7. (this issue) - PubMed
    1. Hendy GN, Bevan S, Mattei MG, et al. Chromogranin A. Clin Invest Med. 1995;18:47–65. - PubMed
    1. Camilleri M, McKinzie S, Busciglio I, et al. Prospective study of motor, sensory, psychologic, and autonomic functions in patients with irritable bowel syndrome. Clin Gastroenterol Hepatol. 2008;6:772–81. - PMC - PubMed
    1. Sidhu R, McAlindon ME, Leeds JS, et al. The role of serum chromogranin A in diarrhoea predominant irritable bowel syndrome. J Gastrointestin Liver Dis. 2009;18:23–6. - PubMed
    1. El-Salhy M, Lomholt-Beck B, Gundersen TD. High chromogranin A cell density in the colon of patients with lymphocytic colitis. Mol Med Report. 2011;4:603–5. - PubMed