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. 2012;7(2):e32739.
doi: 10.1371/journal.pone.0032739. Epub 2012 Feb 28.

Discovery and genomic characterization of noroviruses from a gastroenteritis outbreak in domestic cats in the US

Pierfrancesco Pinto  1 , Qiuhong Wang, Ning Chen, Edward J Dubovi, Joshua B Daniels, Laurie M Millward, Canio Buonavoglia, Vito Martella, Linda J Saif
Affiliations

Discovery and genomic characterization of noroviruses from a gastroenteritis outbreak in domestic cats in the US

Pierfrancesco Pinto et al. PLoS One. 2012.

Abstract

Norovirus (NoV) RNA was detected in the stools of 6 out 14 (42.8%) 8-12-week-old cats with enteritis from a feline shelter, in New York State. Upon sequence analysis of the complete capsid, the six NoVs were found to be identical, suggesting the spread of a unique NoV strain in the shelter. The full-length genomic sequence (7839 nt) of one feline NoV, CU081210E/2010/US, was determined. In the capsid protein VP1 region, the virus displayed the highest amino acid identity to animal genogroup IV genotype 2 (GIV.2) NoVs: lion/Pistoia-387/06/IT (97.9%) and dog/Bari-170/07/IT (90.4%). These findings document the discovery of a novel feline calicivirus, different from vesiviruses, and extend the spectrum of NoV host range. Epidemiological studies using feline NoV-specific diagnostic tools and experimental infection of cats are required to understand whether NoVs have a pathogenic role in this species.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Neighbor-Joining phylogenetic tree of caliciviruses based on the complete genomes (nucleotide).
The newly identified feline NoV CU081210E/10/USA is in bold. Bootstrap values are shown near branches.
Figure 2
Figure 2. Neighbor-Joining phylogenetic tree of noroviruses based on the complete capsid sequence (amino acid).
The newly identified feline NoV CU081210E/10/US is in bold. Bootstrap values are shown near branches.
See this image and copyright information in PMC

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