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. 2011:2011:852619.
doi: 10.5402/2011/852619. Epub 2011 Jul 18.

Two new cytotoxic candidaspongiolides from an indonesian sponge

Agus Trianto  1 , Idam Hermawan, Toshimasa Suzuka, Junichi Tanaka
Affiliations

Two new cytotoxic candidaspongiolides from an indonesian sponge

Agus Trianto et al. ISRN Pharm. 2011.

Abstract

Marine sponges have been recognized as potentially rich sources of various bioactive molecules. In our continuing search for new secondary metabolites from Indonesian marine invertebrates, we collected a sponge, whose extract showed cytotoxicity against cultured cells at 0.1 μg/mL. Purification of the extract yielded two new macrolides 2 and 3 along with known candidaspongiolide (1). The structures for compounds 2 and 3 were elucidated by spectral analysis ((1)H, (13)C, COSY, HMQC, HMBC) and by comparison of their NMR data with those of 1. Compounds 2 and 3 exhibited a little more potent cytotoxicity (IC(50) 4.7 and 19 ng/mL) than that (IC(50) 37 ng/mL) of candidaspongiolide (1) against NBT-T2 cells.

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Figures

Figure 1
Figure 1
Structures of compounds (1)–(4).
See this image and copyright information in PMC

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