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. 2012 Mar;32(2):113-8.
doi: 10.3343/alm.2012.32.2.113. Epub 2012 Feb 23.

Relationship of oxidative stress in hepatitis B infection activity with HBV DNA and fibrosis

Fazilet Duygu  1 , Hasan Karsen, Nurten Aksoy, Abdullah Taskin
Affiliations

Relationship of oxidative stress in hepatitis B infection activity with HBV DNA and fibrosis

Fazilet Duygu et al. Ann Lab Med. 2012 Mar.

Abstract

Background: The aim of this study was to evaluate oxidative stress in various clinical forms of hepatitis B infection and to investigate its role in the development of the chronic form of the disease.

Methods: Ninety-three patients with inactive hepatitis B surface antigen (HbsAg) carrier state (IHBCS), 65 patients with chronic hepatitis B infection (CHB), and 42 healthy adults were included in the study. The following values were measured and compared in patient groups: total antioxidant status (TAS), total oxidative stress (TOS), oxidative stress index (OSI), sulfhydryl (SH), lipid peroxidation (LOOH), catalase (CAT), and ceruloplasmin. In patients with chronic hepatitis B, these values were compared with HBV DNA and fibrosis levels.

Results: ALT, TOS, LOOH, and OSI levels were higher in the CHB group compared to the other groups (P<0.001). Catalase levels increased in the CHB and IHBCS groups compared to the control group (P<0.001). Total aminooxidant and ceruloplasmin levels were found to be lowest in the CHB group and highest in the control group (P<0.001). Sulfhyrdyl was higher in the control group compared to the other groups (P<0.001). In the CHB group, there was no correlation between the HBV DNA and OSI (P>0.05).

Conclusions: These finding suggested that oxidative stress is associated with hepatitis B activity.

Keywords: Catalase; Fibrosis; HBV DNA; Hepatitis B; Oxidative stress; Sulfhydryl.

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Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1
Fig. 1
Oxidative stress index values of patient groups and control group.
Fig. 2
Fig. 2
Totally antioxidant status values of patient groups and control group. Abbreviation: TAX, totally antioxidant status.
Fig. 3
Fig. 3
Ceruloplasmin values of patient groups and control group.
See this image and copyright information in PMC

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