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. 2012 Sep;38(5):914-9.
doi: 10.1093/schbul/sbs011. Epub 2012 Mar 5.

Phencyclidine/schizophrenia: one view toward the past, the other to the future

Edward F Domino  1 , Elliot D Luby
Affiliations

Phencyclidine/schizophrenia: one view toward the past, the other to the future

Edward F Domino et al. Schizophr Bull. 2012 Sep.

Abstract

The history of the chemical synthesis and animal/human pharmacology of phencyclidine is documented. From its early use as a general anesthetic, chemical model of schizophrenia, and drug of abuse, phencyclidine has had a checkered history. Research with this agent and its chemical derivatives like ketamine have provided a solid foundation for just a beginning to understanding the neuropathology of schizophrenia.

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