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. 2012 Jun;56(6):3441-3.
doi: 10.1128/AAC.05682-11. Epub 2012 Mar 5.

Bactericidal activity of multiple combinations of tigecycline and colistin against NDM-1-producing Enterobacteriaceae

Mahableshwar Albur  1 , Alan Noel, Karen Bowker, Alasdair MacGowan
Affiliations

Bactericidal activity of multiple combinations of tigecycline and colistin against NDM-1-producing Enterobacteriaceae

Mahableshwar Albur et al. Antimicrob Agents Chemother. 2012 Jun.

Abstract

The interaction between colistin and tigecycline against eight well-characterized NDM-1-producing Enterobacteriaceae strains was studied. Time-kill methodology was employed using a 4-by-4 exposure matrix with pharmacokinetically achievable free drug peak, trough, and average 24-h serum concentrations. Colistin sulfate and methanesulfonate alone showed good early bactericidal activity, often with subsequent regrowth. Tigecycline alone had poor activity. Addition of tigecycline to colistin does not produce increased bacterial killing; instead, it may cause antagonism at lower concentrations.

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Figures

Fig 1
Fig 1
Antibacterial activities of tigecycline, colistin sulfate, and colistin methanesulfonate against NDM-1-producing Enterobacteriaceae at free peak concentrations of individual drugs (A), free trough concentrations of individual drugs (B), combinations of peak concentrations (C), and combinations of trough concentrations (D).
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