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. 2012 Mar;69(3):293-9.
doi: 10.1001/archgenpsychiatry.2011.1385.

Common heritable contributions to low-risk trauma, high-risk trauma, posttraumatic stress disorder, and major depression

Carolyn E Sartor  1 , Julia D Grant, Michael T Lynskey, Vivia V McCutcheon, Mary Waldron, Dixie J Statham, Kathleen K Bucholz, Pamela A F Madden, Andrew C Heath, Nicholas G Martin, Elliot C Nelson
Affiliations

Common heritable contributions to low-risk trauma, high-risk trauma, posttraumatic stress disorder, and major depression

Carolyn E Sartor et al. Arch Gen Psychiatry. 2012 Mar.

Abstract

Context: Understanding the relative contributions of genetic and environmental factors to trauma exposure, posttraumatic stress disorder (PTSD), and major depressive disorder (MDD) is critical to developing etiologic models of these conditions and their co-occurrence.

Objectives: To quantify heritable influences on low-risk trauma, high-risk trauma, PTSD, and MDD and to estimate the degree of overlap between genetic and environmental sources of variance in these 4 phenotypes.

Design: Adult twins and their siblings were ascertained from a large population-based sample of female and male twin pairs on the basis of screening items for childhood sexual abuse and physical abuse obtained in a previous assessment of this cohort.

Setting: Structured psychiatric telephone interviews.

Participants: Total sample size of 2591: 996 female and 536 male twins; 625 female and 434 male nontwin siblings.

Main outcome measure: Lifetime low- and high-risk trauma exposure, PTSD, and MDD.

Results: In the best-fitting genetic model, 47% of the variance in low-risk trauma exposure and 60% of the variance in high-risk trauma exposure was attributable to additive genetic factors. Heritable influences accounted for 46% of the variance in PTSD and 27% of the variance in MDD. An extremely high degree of genetic overlap was observed between high-risk trauma exposure and both PTSD (r = 0.89; 95% CI, 0.78-0.99) and MDD (r = 0.89; 95% CI, 0.77-0.98). Complete correlation of genetic factors contributing to PTSD and to MDD (r = 1.00) was observed.

Conclusions: The evidence suggests that almost all the heritable influences on high-risk trauma exposure, PTSD, and MDD, can be traced to the same sources; that is, genetic risk is not disorder specific. Individuals with a positive family history of either PTSD or MDD are at elevated risk for both disorders and should be closely monitored after a traumatic experience for symptoms of PTSD and MDD.

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Figures

Figure
Figure
Final quadrivariate model of liability to major depressive disorder (MDD), trauma, and posttraumatic stress disorder (PTSD). Standardized parameter estimates are shown. A1 to A3 denote genetic factors; E1 to E4, nonshared environmental factors.
See this image and copyright information in PMC

References

    1. Resnick HS, Kilpatrick DG, Dansky BS, Saunders BE, Best CL. Prevalence of civilian trauma and posttraumatic stress disorder in a representative national sample of women. J Consult Clin Psychol. 1993;61(6):984–991. - PubMed
    1. Creamer M, Burgess P, McFarlane AC. Post-traumatic stress disorder: findings from the Australian National Survey of Mental Health and Well-being. Psychol Med. 2001;31(7):1237–1247. - PubMed
    1. Breslau N. The epidemiology of trauma, PTSD, and other posttrauma disorders. Trauma Violence Abuse. 2009;10(3):198–210. - PubMed
    1. Kessler RC, Sonnega A, Bromet E, Hughes M, Nelson CB. Posttraumatic stress disorder in the National Comorbidity Survey. Arch Gen Psychiatry. 1995;52(12):1048–1060. - PubMed
    1. Breslau N, Kessler RC, Chilcoat HD, Schultz LR, Davis GC, Andreski P. Trauma and posttraumatic stress disorder in the community: the 1996 Detroit Area Survey of Trauma. Arch Gen Psychiatry. 1998;55(7):626–632. - PubMed

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