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. 2012 Feb;3(2):12.
doi: 10.1258/shorts.2011.011119. Epub 2012 Feb 27.

Health-related quality of life in Cystic Fibrosis patients infected with transmissible Pseudomonas aeruginosa strains: cohort study

Abdul Ashish  1 , Matthew Shaw, James McShane, Martin J Ledson, Martin J Walshaw
Affiliations

Health-related quality of life in Cystic Fibrosis patients infected with transmissible Pseudomonas aeruginosa strains: cohort study

Abdul Ashish et al. JRSM Short Rep. 2012 Feb.

Abstract

Objectives: To assess the impact on health-related quality of life (HRQoL) in adult cystic fibrosis (CF) patients of chronic infection with the Liverpool Epidemic Strain (LES) of Pseudomonas aeruginosa (Psa).

Design: Cohort study.

Participants: Adult CF patients attending a single CF centre.

Setting: Outpatient clinic.

Main outcome measures: HRQoL measures of adult CF patients chronically infected with LES and Psa strains measured by CFQ-UK.

Results: Patients infected by transmissible Psa strains had worse physical functioning, respiratory symptoms, treatment burden, vitality, role, health perception and emotion than those with unique Psa strains (P < 0.01), and significantly poorer physical functioning, respiratory symptoms, treatment burden, body image, weight, role, and emotion than those without any Psa infection (P < 0.05). Furthermore, in a matched cohort of 39 patients, those with LES infection reported significantly worse physical functioning, treatment burden, respiratory symptoms and health perception than those with unique Psa infection (P < 0.02).

Conclusion: Chronic infection with transmissible Psa strains, particularly LES, confers a worse quality of life in adult CF patients. Coupled with the established poorer clinical outcome, this reinforces the need to prevent the spread of such strains in CF community.

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