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Review
. 2012 Mar;2(3):a009407.
doi: 10.1101/cshperspect.a009407.

Leucine-rich repeat kinase 2 for beginners: six key questions

Lauren R Kett  1 , William T Dauer
Affiliations
Review

Leucine-rich repeat kinase 2 for beginners: six key questions

Lauren R Kett et al. Cold Spring Harb Perspect Med. 2012 Mar.

Abstract

There has been intense interest in leucine-rich repeat kinase 2 (LRRK2) since 2004, when mutations in the LRRK2 gene were discovered to cause dominantly inherited Parkinson's disease (PD). This article will address six basic questions about LRRK2 biology as it relates to PD, with particular emphasis on its discovery, current concepts of its physiological and pathological functions, and the strategies being used to discover how LRRK2 dysfunction causes PD.

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Figures

Figure 1.
Figure 1.
Domain structure and Parkinson’s disease mutations of LRRK2. LRR, leucine-rich repeat; GTP, GTPase domain (also called Roc domain, Ras of complex proteins). Five PD-causing missense mutations are shown.
See this image and copyright information in PMC

References

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