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Review
. 2012 Mar;7(3):383-94.
doi: 10.2217/fmb.12.1.

Defense at the border: the blood-brain barrier versus bacterial foreigners

Nina M van Sorge  1 , Kelly S Doran
Affiliations
Review

Defense at the border: the blood-brain barrier versus bacterial foreigners

Nina M van Sorge et al. Future Microbiol. 2012 Mar.

Abstract

Bacterial meningitis is among the top ten causes of infectious disease-related deaths worldwide, with up to half of the survivors left with permanent neurological sequelae. The blood-brain barrier (BBB), composed mainly of specialized brain microvascular endothelial cells, maintains biochemical homeostasis in the CNS by regulating the passage of nutrients, molecules and cells from the blood to the brain. Despite its highly restrictive nature, certain bacterial pathogens are able to gain entry into the CNS resulting in serious disease. In recent years, important advances have been made in understanding the molecular and cellular events that are involved in the development of bacterial meningitis. In this review, we summarize the progress made in elucidating the molecular mechanisms of bacterial BBB-crossing, highlighting common themes of host-pathogen interaction, and the potential role of the BBB in innate defense during infection.

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References

    1. Baraff LJ, Lee SI, Schriger DL. Outcomes of bacterial meningitis in children: a meta-analysis. Pediatr. Infect. Dis. J. 1993;12(5):389–394. - PubMed
    1. Grimwood K, Anderson P, Anderson V, Tan L, Nolan T. Twelve year outcomes following bacterial meningitis: further evidence for persisting effects. Arch. Dis. Child. 2000;83(2):111–116. - PMC - PubMed
    1. Eskola J, Peltola H, Takala AK, et al. Efficacy of Haemophilus influenzae type b polysaccharide-diphtheria toxoid conjugate vaccine in infancy. N. Engl. J. Med. 1987;317(12):717–722. - PubMed
    1. Peltola H. Worldwide Haemophilus influenzae type b disease at the beginning of the 21st century: global ana lysis of the disease burden 25 years after the use of the polysaccharide vaccine and a decade after the advent of conjugates. Clin. Microbiol. Rev. 2000;13(2):302–317. - PMC - PubMed
    1. Watt JP, Wolfson LJ, O’Brien KL, et al. Burden of disease caused by Haemophilus influenzae type b in children younger than 5 years: global estimates. Lancet. 2009;374(9693):903–911. - PubMed

Websites

    1. WHO Health Report 2004. www.who.int/whr/2004/en/report04_en.pdf.
    1. HiB Initiative. www.hibaction.org.

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