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Review
. 2012 Mar 7;13(4):270-6.
doi: 10.1038/nrm3305.

A two-way street: reciprocal regulation of metabolism and signalling

Kathryn E Wellen  1 , Craig B Thompson
Affiliations
Review

A two-way street: reciprocal regulation of metabolism and signalling

Kathryn E Wellen et al. Nat Rev Mol Cell Biol. .

Abstract

It is becoming increasingly clear that cellular signalling and metabolism are not just separate entities but rather are tightly linked. Although nutrient metabolism is known to be regulated by signal transduction, an emerging paradigm is that signalling and transcriptional networks can be modulated by nutrient-sensitive protein modifications, such as acetylation and glycosylation, which depend on the availability of acetyl-CoA and sugar donors such as UDP-N-acetylglucosamine (UDP-GlcNAc), respectively. The integration of metabolic and signalling cues allows cells to modulate activities such as metabolism, cell survival and proliferation according to their intracellular metabolic resources.

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