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Review
. 2012 Apr;153(4):1585-92.
doi: 10.1210/en.2011-2121. Epub 2012 Mar 6.

Minireview: animal models and mechanisms of ovarian cancer development

Lisa K Mullany  1 , JoAnne S Richards
Affiliations
Review

Minireview: animal models and mechanisms of ovarian cancer development

Lisa K Mullany et al. Endocrinology. 2012 Apr.

Abstract

Ovarian cancer in women is a complex and deadly disease, where the molecular events that initiate and control tumor formation remain poorly defined. Therefore, mouse models provide one approach for determining the mechanisms by which specific oncogenic factors cause ovarian surface epithelial cell and granulosa cell transformation. This minireview summarizes the phenotypes of current mouse models that have been generated and some of the underlying mechanisms they have provided.

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Figures

Fig. 1.
Fig. 1.
Schematic of genetic alterations in human ovarian cancers that have been studied in mouse and hen. See text for details. HER2, Human epidermal receptor 2/neutral tumor gene; WNT, Wingless integrated into the genome.
See this image and copyright information in PMC

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