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. 2011 Jun;2(3):186-95.
Epub 2011 Apr 28.

Aging genetics and aging

Sandra Rodríguez-Rodero  1 , Juan Luis Fernández-Morera, Edelmiro Menéndez-Torre, Vincenzo Calvanese, Agustín F Fernández, Mario F Fraga
Affiliations
Free PMC article

Aging genetics and aging

Sandra Rodríguez-Rodero et al. Aging Dis. 2011 Jun.
Free PMC article

Abstract

The process of aging refers to the decay of an organism's structure and function, in which molecular and cellular modifications can have various effects at the individual level over the course of a lifetime. The accumulation of molecular errors that compromise adult stem cell functions occurs because of genetic and epigenetic interactions and depends on hereditary, environmental, and stochastic factors. Here we review the known genetic factors involved in aging.

Keywords: DNA repair and telomeres; Environment; Genes; Longevity; Progerias.

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Figures

Figure 1.
Figure 1.
Representation of genetic factors′ influence in aging and lifespan. The environmental conditions (stress, pesticides), individual genotype (genomic and mitochondrial DNA) and stochastic factors can induce genetic and epigenetic alterations that cause a decline in somatic stem cell function that can be the origin of metabolic, degenerative diseases, cancer and aging in the individuals.
See this image and copyright information in PMC

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