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. 2012 Mar 7;5(1):2.
doi: 10.1186/1756-6614-5-2.

Riedel's thyroiditis - a case report with genes' expression studies

Katarzyna Wojciechowska-Durczyńska  1 , Adam Durczyński, Stanisław Sporny, Janusz Strzelczyk, Andrzej Lewiński
Affiliations

Riedel's thyroiditis - a case report with genes' expression studies

Katarzyna Wojciechowska-Durczyńska et al. Thyroid Res. .

Abstract

Background: Genetic background of Riedel's thyroiditis remains unknown. Herein, we describe our results of studies on genes expression levels in Riedel's thyroiditis.

Case report and genetic findings: We report the case of 48-year old woman with Riedel's thyroiditis who has presented unusual course of disease with non-specific cervical discomfort, though as with no pain and/or no compression symptoms. After surgery, thyroid specimens were quantitatively evaluated, regarding PIK3CA, PIK3CD, PIK3CG, Tg, TGFB1, THRB, COL1, CDKN1C, CDH3 and CACNA2D2 genes expression levels, by real-time PCR in the ABI PRISM® 7500 Sequence Detection System. Out of 10 above genes, in 2 cases the expression was higher than in respective Controls of unchanged thyroid tissue. In the remaining 8 cases, expression in question became comparable or lower as in Controls.

Discussion: The association between increased expression levels of PIK3CA and CDH3 genes and Riedel's thyroiditis is not well-defined. However, the increased expression of PIK3CA and CDH3 genes in our case report and in previous studies of other authors on various malignancies may suggest possible molecular relation between Riedel's thyroiditis and certain neoplastic processes, the relation of which requires further genetic evaluation. It is to be stressed that gene expression studies in Riedel's thyroiditis are difficult to perform, mainly due to fibrosis, resulting in scarce thyroid specimens and - in consequence - small amount of genetic material.

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Figures

Figure 1
Figure 1
Thyroid parenchyma peripherally to dense connective tissue hyperplasia. HE 320 ×.
Figure 2
Figure 2
Thyroid parenchyma remnant among dense connective tissue. HE 320 ×.
Figure 3
Figure 3
Arterial vessel among fibrosing thyroid parenchyma. HE 320 ×.
Figure 4
Figure 4
Thyroid parenchyma peripherally to dense connective tissue hyperplasia. HE 320 ×.
Figure 5
Figure 5
Real-time PCR relative quantification (RQ) of studied genes levels in Riedel's thyroiditis. Bars represents quantification values normalized to an endogenous control (β-actin) and relative to a calibrator (control sample, RQ = 1).
See this image and copyright information in PMC

References

    1. Schwaegerle SM, Bauer TW, Esselstyn CB Jr. Riedel's thyroiditis. Am J Clin Pathol. 1988;6:715–722. Review. - PubMed
    1. Papi G, Corrado S, Cesinaro AM, Novelli L, Smerieri A, Carapezzi C. Riedel's thyroiditis: clinical, pathological and imaging features. Int J Clin Pract. 2002;1:65–67. - PubMed
    1. Fontaine S, Gaches F, Lamant L, Uzan M, Bennet A, Caron P. An unusual form of Riedel's thyroiditis: a case report and review of the literature. Thyroid. 2005;1:85–88. - PubMed
    1. Fatourechi MM, Hay ID, McIver B, Sebo TJ, Fatourechi V. Invasive fibrous thyroiditis (Riedel thyroiditis): the Mayo Clinic experience, 1976-2008. Thyroid. 2011;7:765–772. - PubMed
    1. Junik R, Juraniec O, Pypkowski J, Krymer A, Marszałek A. A difficult diagnosis: a case report of combined Riedel's disease and fibrosing Hashimoto's thyroiditis. Endokrynol Pol. 2011;62(4):351–356. - PubMed

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