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. 2012 Apr 18;48(31):3733-5.
doi: 10.1039/c2cc30773a. Epub 2012 Mar 8.

Design and synthesis of a "click" high-mannose oligosaccharide mimic emulating Man8 binding affinity towards Con A

Virginie Cendret  1 , Marc François-Heude, Alejandro Méndez-Ardoy, Vincent Moreau, José M García Fernández, Florence Djedaïni-Pilard
Affiliations

Design and synthesis of a "click" high-mannose oligosaccharide mimic emulating Man8 binding affinity towards Con A

Virginie Cendret et al. Chem Commun (Camb). .

Abstract

A dendritic "click" mannooligomer mimicking the high-mannose oligosaccharide Man(8) has been designed by replacing some of the inner mannopyranosyl subunits with triazole moieties; evaluation of its binding affinity towards the mannose-specific lectin concanavalin A revealed striking similarities between the "click" mimic and the natural Man(8).

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