Impersonalized medicine
- PMID: 22399263
- DOI: 10.1126/scitranslmed.3003738
Impersonalized medicine
Abstract
Research reported in this issue of Science Translational Medicine illustrates the benefits of short-term food withdrawal (fasting) in the treatment of cancer. Fasting exploited fundamental differences in the way tumor cells and normal cells respond to stress, simultaneously strengthening normal cell function and weakening tumor cell survival in the presence of toxic doses of chemotherapeutic drugs.
Comment on
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Surgical stress resistance induced by single amino acid deprivation requires Gcn2 in mice.Sci Transl Med. 2012 Jan 25;4(118):118ra11. doi: 10.1126/scitranslmed.3002629. Sci Transl Med. 2012. PMID: 22277968 Free PMC article.
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Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy.Sci Transl Med. 2012 Mar 7;4(124):124ra27. doi: 10.1126/scitranslmed.3003293. Epub 2012 Feb 8. Sci Transl Med. 2012. PMID: 22323820 Free PMC article.
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