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. 2012 Mar;32(3):727-31.

Effect of dietary vitamin D and calcium on the growth of androgen-insensitive human prostate tumor in a murine model

Rahul Ray  1 , Mara Banks, Hilal Abuzahra, Vikram J Eddy, Kelly S Persons, M Scott Lucia, James R Lambert, Michael F Holick
Affiliations

Effect of dietary vitamin D and calcium on the growth of androgen-insensitive human prostate tumor in a murine model

Rahul Ray et al. Anticancer Res. 2012 Mar.

Abstract

Vitamin D deficiency has been associated with increased risk of prostate cancer (PC) in epidemiologic and prospective studies. An association has also been made between high dietary calcium and increased PC risk. In this study, we evaluated the effect of dietary vitamin D and calcium on the growth of human androgen-insensitive prostate tumor in an athymic mouse model. We observed highest tumor growth in the normal calcium - vitamin D-deficient group, while tumor growth between the normal calcium - vitamin D-sufficient, high calcium - vitamin D-sufficient and high calcium - vitamin D-deficient diet-groups did not significantly differ but was significantly lower than that in the normal calcium - vitamin D-deficient group. Our results suggest an important role of dietary vitamin D as a preventive agent in androgen-insensitive PC.

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Figures

Figure 1
Figure 1
Tumor growth as a function of time. Starting at day 48, the NCa2+ –D group had a significantly larger tumor volume compared to the other groups (*p<0.05) and this trend continued until the end of the experiment, when this group had the highest tumor volume compared to all other groups.
Figure 2
Figure 2
The weights of the mice at the end of the experiment. There was no significant difference among the groups (n=10).
See this image and copyright information in PMC

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